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PDBsum entry 3vnn

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protein links
Ligase PDB id
3vnn
Jmol
Contents
Protein chain
124 a.a.
Waters ×3
PDB id:
3vnn
Name: Ligase
Title: Crystal structure of a sub-domain of the nucleotidyltransfer (adenylation) domain of human DNA ligase iv
Structure: DNA ligase 4. Chain: a. Fragment: a sub-domain of the nucleotidyltransferase (adeny domain, unp residues 268-405. Synonym: DNA ligase iv, polydeoxyribonucleotide synthase [a engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lig4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.90Å     R-factor:   0.277     R-free:   0.305
Authors: T.Ochi,Q.Wu,D.Y.Chirgadze,J.G.Grossmann,V.M.Bolanos-Garcia, T.L.Blundell
Key ref: T.Ochi et al. (2012). Structural insights into the role of domain flexibility in human DNA ligase IV. Structure, 20, 1212-1222. PubMed id: 22658747 DOI: 10.1016/j.str.2012.04.012
Date:
17-Jan-12     Release date:   20-Jun-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P49917  (DNLI4_HUMAN) -  DNA ligase 4
Seq:
Struc:
 
Seq:
Struc:
911 a.a.
124 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.5.1.1  - Dna ligase (ATP).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m)
ATP
+ (deoxyribonucleotide)(n)
+ (deoxyribonucleotide)(m)
= AMP
+ diphosphate
+ (deoxyribonucleotide)(n+m)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     DNA repair   3 terms 
  Biochemical function     DNA binding     4 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.str.2012.04.012 Structure 20:1212-1222 (2012)
PubMed id: 22658747  
 
 
Structural insights into the role of domain flexibility in human DNA ligase IV.
T.Ochi, Q.Wu, D.Y.Chirgadze, J.G.Grossmann, V.M.Bolanos-Garcia, T.L.Blundell.
 
  ABSTRACT  
 
No abstract given.