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PDBsum entry 3v6s

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protein ligands Protein-protein interface(s) links
Transferase/transferase inhibitor PDB id
3v6s
Jmol
Contents
Protein chains
349 a.a.
Ligands
0F0 ×2
Waters ×215
PDB id:
3v6s
Name: Transferase/transferase inhibitor
Title: Discovery of potent and selective covalent inhibitors of jnk
Structure: Mitogen-activated protein kinase 10. Chain: a, b. Synonym: map kinase 10, mapk 10, map kinase p49 3f12, stres activated protein kinase 1b, sapk1b, stress-activated prote jnk3, c-jun n-terminal kinase 3. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.97Å     R-factor:   0.219     R-free:   0.263
Authors: H.Park,J.D.Laughlin,P.V.Lograsso
Key ref: T.Zhang et al. (2012). Discovery of potent and selective covalent inhibitors of JNK. Chem Biol, 19, 140-154. PubMed id: 22284361 DOI: 10.1016/j.chembiol.2011.11.010
Date:
20-Dec-11     Release date:   01-Feb-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P53779  (MK10_HUMAN) -  Mitogen-activated protein kinase 10
Seq:
Struc:
464 a.a.
349 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     5 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.chembiol.2011.11.010 Chem Biol 19:140-154 (2012)
PubMed id: 22284361  
 
 
Discovery of potent and selective covalent inhibitors of JNK.
T.Zhang, F.Inesta-Vaquera, M.Niepel, J.Zhang, S.B.Ficarro, T.Machleidt, T.Xie, J.A.Marto, N.Kim, T.Sim, J.D.Laughlin, H.Park, P.V.LoGrasso, M.Patricelli, T.K.Nomanbhoy, P.K.Sorger, D.R.Alessi, N.S.Gray.
 
  ABSTRACT  
 
No abstract given.