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PDBsum entry 3v5g

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protein ligands metals links
Lyase/lyase inhibitor PDB id
3v5g
Jmol
Contents
Protein chain
257 a.a.
Ligands
MBO
0F3 ×3
HGB
Metals
_ZN
Waters ×445
PDB id:
3v5g
Name: Lyase/lyase inhibitor
Title: Crystal structure of human carbonic anhydrase ii in complex 4-sulfamido-benzenesulfonamide inhibitor
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, ca carbonic anhydrase ii, ca-ii. Ec: 4.2.1.1
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
1.50Å     R-factor:   0.186     R-free:   0.212
Authors: K.D'Ambrosio,G.De Simone
Key ref: K.D'Ambrosio et al. (2012). Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups. J Med Chem, 55, 6776-6783. PubMed id: 22775345 DOI: 10.1021/jm300818k
Date:
16-Dec-11     Release date:   25-Jul-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   21 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
DOI no: 10.1021/jm300818k J Med Chem 55:6776-6783 (2012)
PubMed id: 22775345  
 
 
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.
K.D'Ambrosio, F.Z.Smaine, F.Carta, G.De Simone, J.Y.Winum, C.T.Supuran.
 
  ABSTRACT  
 
No abstract given.