PDBsum entry 3v2x

Protein binding

PDB id: 3v2x

Contents

Protein chains

166 a.a.

11 a.a.

Waters ×78

PDB id:

3v2x

Name:

Protein binding

Title:

Crystal structure of the peptide bound complex of the ankyrin repeat domains of human ankra2

Structure:

Ankyrin repeat family a protein 2. Chain: a. Fragment: unp residues 148-313 (ank repeats). Synonym: rfxank-like protein 2. Engineered: yes. Low-density lipoprotein receptor-related protein 2. Chain: b. Synonym: lrp-2, glycoprotein 330, gp330, megalin. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ankra, ankra2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Rattus norvegicus. Rat.

Resolution:

1.85Å R-factor: 0.182 R-free: 0.213

Authors:

R.Lam,C.Xu,C.B.Bian,J.Kania,C.Bountra,J.Weigelt,C.H.Arrowsmith, A.M.Edwards,A.Bochkarev,J.Min,Structural Genomics Consortium (Sgc)

Key ref:

C.Xu et al. (2012). Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Sci Signal, 5, ra39. PubMed id: 22649097

Date:

12-Dec-11 Release date: 04-Apr-12

Protein chain

Q9H9E1  (ANRA2_HUMAN) -  Ankyrin repeat family A protein 2 from Homo sapiens

Seq: 313 a.a.

Struc: 166 a.a.*

Protein chain

P98158  (LRP2_RAT) -  Low-density lipoprotein receptor-related protein 2 from Rattus norvegicus

Seq: 4660 a.a.

Struc: 11 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Sci Signal 5:ra39 (2012)

PubMed id: 22649097

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.

C.Xu, J.Jin, C.Bian, R.Lam, R.Tian, R.Weist, L.You, J.Nie, A.Bochkarev, W.Tempel, C.S.Tan, G.A.Wasney, M.Vedadi, G.D.Gish, C.H.Arrowsmith, T.Pawson, X.J.Yang, J.Min.

ABSTRACT

No abstract given.