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PDBsum entry 3uxg

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protein ligands Protein-protein interface(s) links
Transcription PDB id
3uxg
Jmol
Contents
Protein chains
163 a.a.
16 a.a.
Ligands
UNX ×5
Waters ×117
PDB id:
3uxg
Name: Transcription
Title: Crystal structure of rfxank
Structure: DNA-binding protein rfxank. Chain: a. Fragment: unp residues 90-260. Synonym: ankyrin repeat family a protein 1, regulatory fact subunit b, rfx-b, regulatory factor x-associated ankyrin-co protein. Engineered: yes. Mutation: yes. Histone deacetylase 4.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rfxank, ankra1, rfxb. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Resolution:
1.85Å     R-factor:   0.188     R-free:   0.222
Authors: W.Tempel,X.Chao,C.Bian,Y.Li,C.Bountra,J.Weigelt,C.H.Arrowsmi A.M.Edwards,J.Min,Structural Genomics Consortium (Sgc)
Key ref: C.Xu et al. (2012). Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Sci Signal, 5, ra39. PubMed id: 22649097 DOI: 10.1126/scisignal.2002979
Date:
05-Dec-11     Release date:   13-Jun-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
O14593  (RFXK_HUMAN) -  DNA-binding protein RFXANK
Seq:
Struc:
260 a.a.
163 a.a.*
Protein chain
Pfam   ArchSchema ?
P56524  (HDAC4_HUMAN) -  Histone deacetylase 4
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1084 a.a.
16 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chain B: E.C.3.5.1.98  - Histone deacetylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
DOI no: 10.1126/scisignal.2002979 Sci Signal 5:ra39 (2012)
PubMed id: 22649097  
 
 
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
C.Xu, J.Jin, C.Bian, R.Lam, R.Tian, R.Weist, L.You, J.Nie, A.Bochkarev, W.Tempel, C.S.Tan, G.A.Wasney, M.Vedadi, G.D.Gish, C.H.Arrowsmith, T.Pawson, X.J.Yang, J.Min.
 
  ABSTRACT  
 
No abstract given.