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PDBsum entry 3uvc
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PDB id:
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Hydrolase
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Title:
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Mmp12 in a complex with the dimeric adduct: 5-(5-phenylhydantoin)-5- phenylhydantoin
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Structure:
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Macrophage metalloelastase. Chain: a, b. Fragment: catalytic domain, residues 106-263. Synonym: mme, macrophage elastase, me, hme, matrix metalloproteinase- 12, mmp-12. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: 4321, hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.30Å
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R-factor:
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0.132
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R-free:
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0.174
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Authors:
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D.J.Derbyshire,H.Danielson,S.Nystrum
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Key ref:
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H.Nordstrom
et al.
Characterization of fragments interacting with mmp-12.
To be published,
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Date:
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29-Nov-11
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Release date:
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02-Jan-13
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PROCHECK
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Headers
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References
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P39900
(MMP12_HUMAN) -
Macrophage metalloelastase from Homo sapiens
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Seq:
Struc:
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470 a.a.
158 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.4.24.65
- macrophage elastase.
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Reaction:
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Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
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Cofactor:
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Ca(2+); Zn(2+)
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Links
