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PDBsum entry 3us8

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
3us8
Jmol
Contents
Protein chains
401 a.a.
Ligands
SO4 ×2
Waters ×363
PDB id:
3us8
Name: Oxidoreductase
Title: Crystal structure of an isocitrate dehydrogenase from sinorh meliloti 1021
Structure: Isocitrate dehydrogenase [nadp]. Chain: a, b. Engineered: yes
Source: Sinorhizobium meliloti. Ensifer meliloti. Organism_taxid: 266834. Strain: 1021. Gene: icd, r01792, smc00480. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.25Å     R-factor:   0.182     R-free:   0.237
Authors: D.Kumaran,S.Chamala,B.Evans,R.Foti,A.Gizzi,B.Hillerich,A.Kar J.Lafleur,R.Seidel,G.Villigas,W.Zencheck,S.C.Almo,S.Swamina York Structural Genomics Research Consortium (Nysgrc)
Key ref: D.Kumaran et al. Crystal structure of an isocitrate dehydrogenase from sinorhizobium meliloti 1021. To be published, .
Date:
23-Nov-11     Release date:   14-Dec-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q92PG6  (Q92PG6_RHIME) -  Isocitrate dehydrogenase [NADP]
Seq:
Struc:
404 a.a.
401 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.42  - Isocitrate dehydrogenase (NADP(+)).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Citric acid cycle
      Reaction: Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH
Isocitrate
+ NADP(+)
= 2-oxoglutarate
+ CO(2)
+ NADPH
      Cofactor: Mn(2+) or Mg(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   3 terms 
  Biochemical function     oxidoreductase activity     6 terms