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PDBsum entry 3unj

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protein ligands links
Transferase/transferase inhibitor PDB id
3unj
Jmol
Contents
Protein chain
294 a.a.
Ligands
0BX
PO4
Waters ×214
PDB id:
3unj
Name: Transferase/transferase inhibitor
Title: Cdk2 in complex with inhibitor yl1-038-31
Structure: Cyclin-dependent kinase 2. Chain: a. Synonym: cell division protein kinase 2, p33 protein kinase engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.90Å     R-factor:   0.199     R-free:   0.261
Authors: J.-Y.Zhu,M.P.Martin,R.Alam,E.Schonbrunn
Key ref: M.P.Martin et al. (2012). A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. ACS Chem Biol, 7, 698-706. PubMed id: 22248356 DOI: 10.1021/cb200508b
Date:
15-Nov-11     Release date:   25-Jan-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
294 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms  

 

 
    reference    
 
 
DOI no: 10.1021/cb200508b ACS Chem Biol 7:698-706 (2012)
PubMed id: 22248356  
 
 
A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.
M.P.Martin, J.Y.Zhu, H.R.Lawrence, R.Pireddu, Y.Luo, R.Alam, S.Ozcan, S.M.Sebti, N.J.Lawrence, E.Schönbrunn.
 
  ABSTRACT  
 
No abstract given.