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PDBsum entry 3tkz

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protein ligands links
Hydrolase/peptide PDB id
3tkz
Jmol
Contents
Protein chain
100 a.a.
Ligands
VAL-ILE-PTR-PHE-
VAL-PRO-LEU
VAL-ILE-PTR-PHE-
VAL-PRO
Waters ×81
PDB id:
3tkz
Name: Hydrolase/peptide
Title: Structure of the shp-2 n-sh2 domain in a 1:2 complex with rv peptide
Structure: Tyrosine-protein phosphatase non-receptor type 11 chain: a. Fragment: n-terminal sh2 domain (unp residues 1-106). Synonym: protein-tyrosine phosphatase 1d, ptp-1d, protein-t phosphatase 2c, ptp-2c, sh-ptp2, shp-2, shp2, sh-ptp3. Engineered: yes. Protein (rvipyfvplnr peptide). Chain: p, q. Engineered: yes.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn11, ptp2c, shptp2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was synthesized using standard f chemistry
Resolution:
1.80Å     R-factor:   0.198     R-free:   0.216
Authors: Y.Zhang,J.Zhang,C.Yuan,R.L.Hard,I.H.Park,C.Li,C.E.Bell,D.Pei
Key ref: Y.Zhang et al. (2011). Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 7637-7646. PubMed id: 21800896 DOI: 10.1021/bi200439v
Date:
29-Aug-11     Release date:   26-Oct-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q06124  (PTN11_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 11
Seq:
Struc:
 
Seq:
Struc:
597 a.a.
100 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
Bound ligand (Het Group name = PTR)
matches with 76.19% similarity
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
DOI no: 10.1021/bi200439v Biochemistry 50:7637-7646 (2011)
PubMed id: 21800896  
 
 
Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain.
Y.Zhang, J.Zhang, C.Yuan, R.L.Hard, I.H.Park, C.Li, C.Bell, D.Pei.
 
  ABSTRACT  
 
No abstract given.