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PDBsum entry 3tiy

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protein ligands links
Transferase/transferase inhibitor PDB id
3tiy
Jmol
Contents
Protein chain
293 a.a.
Ligands
EDO ×12
TIY
Waters ×151
PDB id:
3tiy
Name: Transferase/transferase inhibitor
Title: Cdk2 in complex with nsc 35676
Structure: Cyclin-dependent kinase 2. Chain: a. Synonym: cell division protein kinase 2, p33 protein kinase engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.84Å     R-factor:   0.184     R-free:   0.224
Authors: R.Alam,E.Schonbrunn
Key ref: M.P.Martin et al. (2012). A novel approach to the discovery of small-molecule ligands of CDK2. Chembiochem, 13, 2128-2136. PubMed id: 22893598
Date:
22-Aug-11     Release date:   22-Aug-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
293 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms  

 

 
    reference    
 
 
Chembiochem 13:2128-2136 (2012)
PubMed id: 22893598  
 
 
A novel approach to the discovery of small-molecule ligands of CDK2.
M.P.Martin, R.Alam, S.Betzi, D.J.Ingles, J.Y.Zhu, E.Schönbrunn.
 
  ABSTRACT  
 
No abstract given.