PDBsum entry 3tcp

Transferase/transferase inhibitor

PDB id: 3tcp

Contents

Protein chain

256 a.a.

Ligands

CKJ ×2

Metals

_CA ×3

_CL ×3

Waters ×36

PDB id:

3tcp

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc569

Structure:

Tyrosine-protein kinase mer. Chain: a, b. Fragment: catalytic domain, unp residues 570-864. Synonym: proto-oncogenE C-mer, receptor tyrosine kinase mertk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.69Å R-factor: 0.228 R-free: 0.298

Authors:

J.Liu,C.Yang,C.Simpson,D.Deryckere,A.Van Deusen,M.Miley,D.B.Kireev, J.Norris-Drouin,S.Sather,D.Hunter,H.S.Patel,W.P.Janzen,M.Machius, G.Johnson,H.S.Earp,D.K.Graham,S.Frye,X.Wang

Key ref:

J.Liu et al. (2012). Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. Acs Med Chem Lett, 3, 129-134. PubMed id: 22662287

Date:

09-Aug-11 Release date: 20-Jun-12

Protein chains

Q12866  (MERTK_HUMAN) -  Tyrosine-protein kinase Mer from Homo sapiens

Seq: 999 a.a.

Struc: 256 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Acs Med Chem Lett 3:129-134 (2012)

PubMed id: 22662287

Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.

J.Liu, C.Yang, C.Simpson, D.Deryckere, A.Van Deusen, M.J.Miley, D.Kireev, J.Norris-Drouin, S.Sather, D.Hunter, V.K.Korboukh, H.S.Patel, W.P.Janzen, M.Machius, G.L.Johnson, H.S.Earp, D.K.Graham, S.V.Frye, X.Wang.

ABSTRACT

No abstract given.