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PDBsum entry 3tc5

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protein ligands links
Isomerase/isomerase inhibitor PDB id
3tc5
Jmol
Contents
Protein chain
144 a.a.
Ligands
3T5
P6G
Waters ×266
PDB id:
3tc5
Name: Isomerase/isomerase inhibitor
Title: Selective targeting of disease-relevant protein binding doma phosphorylated natural product derivatives
Structure: Peptidyl-prolyl cis-trans isomerase nima-interact chain: a. Fragment: peptidyl-prolyl cis-trans isomerase nima-interact synonym: peptidyl-prolyl cis-trans isomerase pin1, ppiase p rotamase pin1. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pin1. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.40Å     R-factor:   0.177     R-free:   0.211
Authors: M.Graeber,W.Janczyk,B.Sperl,N.Elumalai,C.Kozany,F.Hausch,T.A T.Berg
Key ref: M.Gräber et al. (2011). Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives. ACS Chem Biol, 6, 1008-1014. PubMed id: 21797253 DOI: 10.1021/cb2001796
Date:
08-Aug-11     Release date:   31-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q13526  (PIN1_HUMAN) -  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Seq:
Struc:
163 a.a.
144 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     midbody   5 terms 
  Biological process     negative regulation of cell motility   15 terms 
  Biochemical function     protein binding     7 terms  

 

 
    Added reference    
 
 
DOI no: 10.1021/cb2001796 ACS Chem Biol 6:1008-1014 (2011)
PubMed id: 21797253  
 
 
Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives.
M.Gräber, W.Janczyk, B.Sperl, N.Elumalai, C.Kozany, F.Hausch, T.A.Holak, T.Berg.
 
  ABSTRACT  
 
No abstract given.