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PDBsum entry 3t84

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protein ligands metals links
Lyase/lyase inhibitor PDB id
3t84
Jmol
Contents
Protein chain
257 a.a.
Ligands
SG6
Metals
_ZN
Waters ×224
PDB id:
3t84
Name: Lyase/lyase inhibitor
Title: Human carbonic anhydrase ii in complex with acetylated carbo sulfamates
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, ca carbonic anhydrase ii, ca-ii. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.00Å     R-factor:   0.161     R-free:   0.206
Authors: A.Hofmann,C.K.Wang
Key ref: M.Lopez et al. (2011). Promiscuity of carbonic anhydrase II. Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors. J Am Chem Soc, 133, 18452-18462. PubMed id: 21958118 DOI: 10.1021/ja207855c
Date:
01-Aug-11     Release date:   19-Oct-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zinc
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   10 terms 
  Biological process     angiotensin-mediated signaling pathway   20 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
DOI no: 10.1021/ja207855c J Am Chem Soc 133:18452-18462 (2011)
PubMed id: 21958118  
 
 
Promiscuity of carbonic anhydrase II. Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors.
M.Lopez, H.Vu, C.K.Wang, M.G.Wolf, G.Groenhof, A.Innocenti, C.T.Supuran, S.A.Poulsen.
 
  ABSTRACT  
 
No abstract given.