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PDBsum entry 3t1e

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protein Protein-protein interface(s) links
Hydrolase PDB id
3t1e
Jmol
Contents
Protein chains
447 a.a.
37 a.a.
PDB id:
3t1e
Name: Hydrolase
Title: The structure of the newcastle disease virus hemagglutinin- neuraminidase (hn) ectodomain reveals a 4-helix bundle stal
Structure: Hemagglutinin-neuraminidase. Chain: a, b, e, f. Fragment: ndv hn ectodomain. Engineered: yes
Source: Newcastle disease virus. Ndv. Organism_taxid: 11177. Strain: chicken/australia-victoria/32. Gene: hn. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: hi5, sf plus
Resolution:
3.30Å     R-factor:   0.251     R-free:   0.310
Authors: P.Yuan,K.Swanson,G.P.Leser,R.G.Paterson,R.A.Lamb,T.S.Jardetz
Key ref: P.Yuan et al. (2011). Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. Proc Natl Acad Sci U S A, 108, 14920-14925. PubMed id: 21873198
Date:
21-Jul-11     Release date:   07-Sep-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P12554  (HN_NDVA) -  Hemagglutinin-neuraminidase
Seq:
Struc:
 
Seq:
Struc:
570 a.a.
447 a.a.*
Protein chains
Pfam   ArchSchema ?
P12554  (HN_NDVA) -  Hemagglutinin-neuraminidase
Seq:
Struc:
 
Seq:
Struc:
570 a.a.
37 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chains A, B, E, F: E.C.3.2.1.18  - Exo-alpha-sialidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     virion   7 terms 
  Biological process     metabolic process   5 terms 
  Biochemical function     exo-alpha-(2->3)-sialidase activity     6 terms  

 

 
Proc Natl Acad Sci U S A 108:14920-14925 (2011)
PubMed id: 21873198  
 
 
Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk.
P.Yuan, K.A.Swanson, G.P.Leser, R.G.Paterson, R.A.Lamb, T.S.Jardetzky.
 
  ABSTRACT  
 
No abstract given.