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PDBsum entry 3sme

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protein metals links
Hydrolase PDB id
3sme
Jmol
Contents
Protein chain
282 a.a.
Metals
_MG
Waters ×170
PDB id:
3sme
Name: Hydrolase
Title: Structure of ptp1b inactivated by h2o2/bicarbonate
Structure: Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Fragment: ptp1b catalytic domain residues 1-298. Synonym: protein-tyrosine phosphatase 1b, ptp-1b. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptp1b, ptpn1. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.70Å     R-factor:   0.198     R-free:   0.210
Authors: J.J.Tanner,H.Singh
Key ref: H.Zhou et al. (2011). The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases. J Am Chem Soc, 133, 15803-15805. PubMed id: 21913686 DOI: 10.1021/ja2077137
Date:
27-Jun-11     Release date:   19-Oct-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18031  (PTN1_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 1
Seq:
Struc:
435 a.a.
282 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms  

 

 
    reference    
 
 
DOI no: 10.1021/ja2077137 J Am Chem Soc 133:15803-15805 (2011)
PubMed id: 21913686  
 
 
The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases.
H.Zhou, H.Singh, Z.D.Parsons, S.M.Lewis, S.Bhattacharya, D.R.Seiner, J.N.LaButti, T.J.Reilly, J.J.Tanner, K.S.Gates.
 
  ABSTRACT  
 
No abstract given.