spacer
spacer

PDBsum entry 3sj7

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
3sj7
Jmol
Contents
Protein chains
239 a.a.
Ligands
NDP ×2
PG4 ×3
Waters ×94
PDB id:
3sj7
Name: Oxidoreductase
Title: Structure of beta-ketoacetyl-coa reductase (fabg) from staph aureus complex with NADPH
Structure: 3-oxoacyl-(acyl-carrier-protein) reductase. Chain: a, b. Synonym: beta-ketoacetyl-coa reductase, fabg. Engineered: yes
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 93061. Strain: nctc 8325. Gene: saouhsc_01199. Expressed in: escherichia coli. Expression_system_taxid: 1007065.
Resolution:
2.50Å     R-factor:   0.181     R-free:   0.253
Authors: D.Dutta,S.Bhattacharyya,A.K.Das
Key ref: D.Dutta et al. (2012). Crystal structure and fluorescence studies reveal the role of helical dimeric interface of staphylococcal FabG1 in positive cooperativity for NADPH. Proteins, 80, 1250-1257. PubMed id: 22275129
Date:
21-Jun-11     Release date:   25-Jan-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q2FZ53  (Q2FZ53_STAA8) -  3-oxoacyl-(Acyl-carrier-protein) reductase, putative
Seq:
Struc:
244 a.a.
239 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.100  - 3-oxoacyl-[acyl-carrier-protein] reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl- carrier-protein] + NADPH
(3R)-3-hydroxyacyl-[acyl-carrier-protein]
+ NADP(+)
= 3-oxoacyl-[acyl- carrier-protein]
+ NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   3 terms 
  Biochemical function     nucleotide binding     4 terms  

 

 
    reference    
 
 
Proteins 80:1250-1257 (2012)
PubMed id: 22275129  
 
 
Crystal structure and fluorescence studies reveal the role of helical dimeric interface of staphylococcal FabG1 in positive cooperativity for NADPH.
D.Dutta, S.Bhattacharyya, A.K.Das.
 
  ABSTRACT  
 
No abstract given.