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PDBsum entry 3sff

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protein ligands metals links
Hydrolase/hydrolase inhibitor PDB id
3sff
Jmol
Contents
Protein chain
341 a.a.
Ligands
0DI
Metals
_ZN
__K ×2
Waters ×234
PDB id:
3sff
Name: Hydrolase/hydrolase inhibitor
Title: Crystal structure of human hdac8 inhibitor complex, an amino derived inhibitor
Structure: Histone deacetylase 8. Chain: a. Synonym: hdac8, hd8. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hdac8, hdacl1, cda07. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Resolution:
2.00Å     R-factor:   0.179     R-free:   0.221
Authors: T.Stams,B.Vash
Key ref: L.Whitehead et al. (2011). Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg Med Chem, 19, 4626-4634. PubMed id: 21723733
Date:
13-Jun-11     Release date:   20-Jul-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9BY41  (HDAC8_HUMAN) -  Histone deacetylase 8
Seq:
Struc:
377 a.a.
341 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.5.1.98  - Histone deacetylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     plasma membrane   7 terms 
  Biological process     mitotic cell cycle   14 terms 
  Biochemical function     hydrolase activity     11 terms  

 

 
Bioorg Med Chem 19:4626-4634 (2011)
PubMed id: 21723733  
 
 
Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
L.Whitehead, M.R.Dobler, B.Radetich, Y.Zhu, P.W.Atadja, T.Claiborne, J.E.Grob, A.McRiner, M.R.Pancost, A.Patnaik, W.Shao, M.Shultz, R.Tichkule, R.A.Tommasi, B.Vash, P.Wang, T.Stams.
 
  ABSTRACT  
 
No abstract given.