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PDBsum entry 3sfe

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
3sfe
Jmol
Contents
Protein chains
613 a.a.
240 a.a.
139 a.a.
102 a.a.
Ligands
FAD
OAA
FES
SF4
F3S
HEM
TMG
Waters ×52
PDB id:
3sfe
Name: Oxidoreductase
Title: Crystal structure of porcine mitochondrial respiratory compl bound with oxaloacetate and thiabendazole
Structure: Succinate dehydrogenase [ubiquinone] flavoprotein mitochondrial. Chain: a. Synonym: flavoprotein subunit of complex ii, fp. Succinate dehydrogenase [ubiquinone] iron-sulfur mitochondrial. Chain: b. Synonym: iron-sulf protein, iron-sulfur subunit of complex succinate dehydrogenase cytochrome b560 subunit,
Source: Sus scrofa. Pigs. Organism_taxid: 9823. Organism_taxid: 9823
Resolution:
2.81Å     R-factor:   0.217     R-free:   0.270
Authors: Q.J.Zhou,Y.J.Zhai,M.Liu,F.Sun
Key ref: Q.Zhou et al. (2011). Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature. Protein Cell, 2, 531-542. PubMed id: 21822798 DOI: 10.1007/s13238-011-1079-1
Date:
13-Jun-11     Release date:   07-Sep-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q0QF01  (DHSA_PIG) -  Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Seq:
Struc:
 
Seq:
Struc:
664 a.a.
613 a.a.
Protein chain
Pfam   ArchSchema ?
Q007T0  (DHSB_PIG) -  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Seq:
Struc:
280 a.a.
240 a.a.
Protein chain
Pfam   ArchSchema ?
D0VWV4  (C560_PIG) -  Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Seq:
Struc:
169 a.a.
139 a.a.
Protein chain
Pfam   ArchSchema ?
A5GZW8  (DHSD_PIG) -  Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Seq:
Struc:
159 a.a.
102 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.1.3.5.1  - Succinate dehydrogenase (quinone).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Citric acid cycle
      Reaction: Succinate + a quinone = fumarate + a quinol
Succinate
Bound ligand (Het Group name = OAA)
matches with 88.89% similarity
+ quinone
= fumarate
+ quinol
      Cofactor: FAD; Iron-sulfur
FAD
Bound ligand (Het Group name = FAD) corresponds exactly
Iron-sulfur
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   7 terms 
  Biological process     oxidation-reduction process   3 terms 
  Biochemical function     electron carrier activity     13 terms  

 

 
    reference    
 
 
DOI no: 10.1007/s13238-011-1079-1 Protein Cell 2:531-542 (2011)
PubMed id: 21822798  
 
 
Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature.
Q.Zhou, Y.Zhai, J.Lou, M.Liu, X.Pang, F.Sun.
 
  ABSTRACT  
 
No abstract given.