PDBsum entry 3scm

Immune system

PDB id: 3scm

Contents

Protein chains

289 a.a.

99 a.a.

191 a.a.

239 a.a.

Ligands

NAG-NAG

NAG ×2

LGN

Waters ×129

PDB id:

3scm

Name:

Immune system

Title:

Crystal structure of autoreactive-valpha14-vbeta6 nkt tcr in complex with cd1d-isoglobotrihexosylceramide

Structure:

Antigen-presenting glycoprotein cd1d1. Chain: a. Fragment: extracellular domain, unp residues 19-297. Engineered: yes. Beta-2-microglobulin. Chain: b. Fragment: extracellular domain, unp residues 21-119. Engineered: yes. Nkt tcr valpha14 chain.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: cd1d1, cd1.1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: hi5. Gene: b2m. Mus musculus , homo sapiens.

Resolution:

2.50Å R-factor: 0.275 R-free: 0.318

Authors:

A.J.Clarke,J.Rossjohn

Key ref:

D.G.Pellicci et al. (2011). Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol, 12, 827-833. PubMed id: 21804559

Date:

08-Jun-11 Release date: 05-Oct-11

Protein chain

P11609  (CD1D1_MOUSE) -  Antigen-presenting glycoprotein CD1d1 from Mus musculus

Seq: 336 a.a.

Struc: 289 a.a.*

Protein chain

P01887  (B2MG_MOUSE) -  Beta-2-microglobulin from Mus musculus

Seq: 119 a.a.

Struc: 99 a.a.

Protein chain

P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens

Seq: 140 a.a.

Struc: 191 a.a.*

Protein chain

No UniProt id for this chain

Struc: 239 a.a.

* PDB and UniProt seqs differ at 18 residue positions (black crosses)

Nat Immunol 12:827-833 (2011)

PubMed id: 21804559

Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors.

D.G.Pellicci, A.J.Clarke, O.Patel, T.Mallevaey, T.Beddoe, J.Le Nours, A.P.Uldrich, J.McCluskey, G.S.Besra, S.A.Porcelli, L.Gapin, D.I.Godfrey, J.Rossjohn.

ABSTRACT

No abstract given.