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PDBsum entry 3sbe

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protein ligands metals links
Hydrolase PDB id
3sbe
Jmol
Contents
Protein chain
178 a.a.
Ligands
GNP
Metals
_MG
Waters ×23
PDB id:
3sbe
Name: Hydrolase
Title: Crystal structure of rac1 p29s mutant
Structure: Ras-related c3 botulinum toxin substrate 1. Chain: a. Synonym: cell migration-inducing gene 5 protein, ras-like p tc25, p21-rac1. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rac1, tc25, mig5. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.60Å     R-factor:   0.234     R-free:   0.296
Authors: B.H.Ha,T.J.Boggon
Key ref: M.Krauthammer et al. (2012). Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet, 44, 1006-1014. PubMed id: 22842228
Date:
03-Jun-11     Release date:   18-Jul-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P63000  (RAC1_HUMAN) -  Ras-related C3 botulinum toxin substrate 1
Seq:
Struc:
192 a.a.
178 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   17 terms 
  Biological process     epithelial cell morphogenesis   63 terms 
  Biochemical function     nucleotide binding     10 terms  

 

 
Nat Genet 44:1006-1014 (2012)
PubMed id: 22842228  
 
 
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
M.Krauthammer, Y.Kong, B.H.Ha, P.Evans, A.Bacchiocchi, J.P.McCusker, E.Cheng, M.J.Davis, G.Goh, M.Choi, S.Ariyan, D.Narayan, K.Dutton-Regester, A.Capatana, E.C.Holman, M.Bosenberg, M.Sznol, H.M.Kluger, D.E.Brash, D.F.Stern, M.A.Materin, R.S.Lo, S.Mane, S.Ma, K.K.Kidd, N.K.Hayward, R.P.Lifton, J.Schlessinger, T.J.Boggon, R.Halaban.
 
  ABSTRACT  
 
No abstract given.