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PDBsum entry 3s97

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protein ligands Protein-protein interface(s) links
Cell adhesion PDB id
3s97
Jmol
Contents
Protein chains
266 a.a.
197 a.a.
Ligands
NAG ×4
Waters ×167
PDB id:
3s97
Name: Cell adhesion
Title: Ptprz cntn1 complex
Structure: Receptor-type tyrosine-protein phosphatase zeta. Chain: a, b. Fragment: carbonic anhydrase like domain (unp residues 34-3 synonym: r-ptp-zeta, protein-tyrosine phosphatase receptor polypeptide 1, protein-tyrosine phosphatase receptor type z polypeptide 2, r-ptp-zeta-2. Engineered: yes. Contactin-1. Chain: c, d.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: htpzp2, ptprz, ptprz1, ptprz2, ptpz. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cntn1. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Resolution:
2.30Å     R-factor:   0.203     R-free:   0.255
Authors: S.Bouyain
Key ref: S.Lamprianou et al. (2011). A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proc Natl Acad Sci U S A, 108, 17498-17503. PubMed id: 21969550 DOI: 10.1073/pnas.1108774108
Date:
31-May-11     Release date:   28-Sep-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P23471  (PTPRZ_HUMAN) -  Receptor-type tyrosine-protein phosphatase zeta
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
2315 a.a.
266 a.a.
Protein chains
Pfam   ArchSchema ?
Q12860  (CNTN1_HUMAN) -  Contactin-1
Seq:
Struc:
 
Seq:
Struc:
1018 a.a.
197 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
=
protein tyrosine
Bound ligand (Het Group name = NAG)
matches with 47.62% similarity
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
DOI no: 10.1073/pnas.1108774108 Proc Natl Acad Sci U S A 108:17498-17503 (2011)
PubMed id: 21969550  
 
 
A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells.
S.Lamprianou, E.Chatzopoulou, J.L.Thomas, S.Bouyain, S.Harroch.
 
  ABSTRACT  
 
No abstract given.