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PDBsum entry 3s4s

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protein ligands Protein-protein interface(s) links
Immune system PDB id
3s4s
Jmol
Contents
Protein chains
178 a.a.
186 a.a.
13 a.a.
176 a.a.
Ligands
GOL ×3
Waters ×68
PDB id:
3s4s
Name: Immune system
Title: Crystal structure of cd4 mutant bound to hla-dr1
Structure: Hla class ii histocompatibility antigen, dr alpha chain: a, d. Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 b chain: b, e. Fragment: unp residues 30-221. Synonym: mhc class ii antigen drb1 1, Dr-1, dr1.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: hla-drb1. Gene: cd4. Expressed in: spodoptera frugiperda.
Resolution:
2.40Å     R-factor:   0.251     R-free:   0.286
Authors: Y.Li
Key ref: X.X.Wang et al. (2011). Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc Natl Acad Sci U S A, 108, 15960-15965. PubMed id: 21900604 DOI: 10.1073/pnas.1109438108
Date:
20-May-11     Release date:   21-Sep-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
Seq:
Struc:
254 a.a.
178 a.a.*
Protein chains
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
Seq:
Struc:
266 a.a.
186 a.a.*
Protein chains
Pfam   ArchSchema ?
P03437  (HEMA_I68A0) -  Hemagglutinin
Seq:
Struc:
 
Seq:
Struc:
566 a.a.
13 a.a.
Protein chains
Pfam   ArchSchema ?
P01730  (CD4_HUMAN) -  T-cell surface glycoprotein CD4
Seq:
Struc:
458 a.a.
176 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   3 terms 
  Biological process     immune response   3 terms 

 

 
DOI no: 10.1073/pnas.1109438108 Proc Natl Acad Sci U S A 108:15960-15965 (2011)
PubMed id: 21900604  
 
 
Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
X.X.Wang, Y.Li, Y.Yin, M.Mo, Q.Wang, W.Gao, L.Wang, R.A.Mariuzza.
 
  ABSTRACT  
 
No abstract given.