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PDBsum entry 3s4e

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protein ligands links
Hydrolase PDB id
3s4e
Jmol
Contents
Protein chain
144 a.a.
Ligands
PO4
SO4 ×2
Waters ×210
PDB id:
3s4e
Name: Hydrolase
Title: Crystal structrue of a novel mitogen-activated protein kinas phosphatase, skrp1
Structure: Dual specificity protein phosphatase 19. Chain: a. Fragment: ptp-loop (unp residues 65-206). Synonym: dual specificity phosphatase ts-dsp1, low molecula dual specificity phosphatase 3, lmw-dsp3, protein phosphata stress-activated protein kinase pathway-regulating phosphat sapk pathway-regulating phosphatase 1. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dusp19, dusp17, lmwdsp3, skrp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.26Å     R-factor:   0.152     R-free:   0.181
Authors: C.H.Wei,S.Y.Ryu,Y.H.Jeon,D.G.Jeong,S.J.Kim,S.E.Ryu
Key ref: C.H.Wei et al. (2011). Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. Proteins, 79, 3242-3246. PubMed id: 21989941
Date:
19-May-11     Release date:   04-Apr-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8WTR2  (DUS19_HUMAN) -  Dual specificity protein phosphatase 19
Seq:
Struc:
217 a.a.
144 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 2: E.C.3.1.3.16  - Protein-serine/threonine phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: [a protein]-serine/threonine phosphate + H2O = [a protein]- serine/threonine + phosphate
[a protein]-serine/threonine phosphate
+ H(2)O
= [a protein]- serine/threonine
+ phosphate
   Enzyme class 3: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms  

 

 
    reference    
 
 
Proteins 79:3242-3246 (2011)
PubMed id: 21989941  
 
 
Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1.
C.H.Wei, S.Y.Ryu, Y.H.Jeon, M.Y.Yoon, D.G.Jeong, S.J.Kim, S.E.Ryu.
 
  ABSTRACT  
 
No abstract given.