spacer
spacer

PDBsum entry 3rj7

Go to PDB code: 
protein ligands metals links
Lyase/lyase inhibitor PDB id
3rj7
Jmol
Contents
Protein chain
258 a.a.
Ligands
MBO
RCS ×2
DMS
Metals
_ZN
Waters ×333
PDB id:
3rj7
Name: Lyase/lyase inhibitor
Title: Human carbonic anhydrase ii complexed with its inhibitor rhe triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene- sulfonamide
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, ca carbonic anhydrase ii, ca-ii. Engineered: yes
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Resolution:
1.20Å     R-factor:   0.166     R-free:   0.190
Authors: B.Spingler,D.Can,R.Alberto
Key ref: D.Can et al. (2012). [(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX. Angew Chem Int Ed Engl, 51, 3354-3357. PubMed id: 22344779
Date:
15-Apr-11     Release date:   29-Feb-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
258 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   21 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
Angew Chem Int Ed Engl 51:3354-3357 (2012)
PubMed id: 22344779  
 
 
[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX.
D.Can, B.Spingler, P.Schmutz, F.Mendes, P.Raposinho, C.Fernandes, F.Carta, A.Innocenti, I.Santos, C.T.Supuran, R.Alberto.
 
  ABSTRACT  
 
No abstract given.