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PDBsum entry 3rgo

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protein ligands links
Hydrolase PDB id
3rgo
Jmol
Contents
Protein chain
157 a.a.
Ligands
SO4 ×2
Waters ×48
PDB id:
3rgo
Name: Hydrolase
Title: Crystal structure of ptpmt1
Structure: Protein-tyrosine phosphatase mitochondrial 1. Chain: a. Synonym: pten-like phosphatase, phosphoinositide lipid phos engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: plip, ptpmt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.93Å     R-factor:   0.228     R-free:   0.243
Authors: J.Xiao,J.L.Engel
Key ref: J.Xiao et al. (2011). Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc Natl Acad Sci U S A, 108, 11860-11865. PubMed id: 21730175 DOI: 10.1073/pnas.1109290108
Date:
08-Apr-11     Release date:   06-Jul-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q66GT5  (PTPM1_MOUSE) -  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Seq:
Struc:
193 a.a.
157 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: E.C.3.1.3.16  - Protein-serine/threonine phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: [a protein]-serine/threonine phosphate + H2O = [a protein]- serine/threonine + phosphate
[a protein]-serine/threonine phosphate
+ H(2)O
= [a protein]- serine/threonine
+ phosphate
   Enzyme class 3: E.C.3.1.3.27  - Phosphatidylglycerophosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate
Phosphatidylglycerophosphate
+ H(2)O
= phosphatidylglycerol
+ phosphate
   Enzyme class 4: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     3 terms  

 

 
    reference    
 
 
DOI no: 10.1073/pnas.1109290108 Proc Natl Acad Sci U S A 108:11860-11865 (2011)
PubMed id: 21730175  
 
 
Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
J.Xiao, J.L.Engel, J.Zhang, M.J.Chen, G.Manning, J.E.Dixon.
 
  ABSTRACT  
 
No abstract given.