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PDBsum entry 3rdp

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protein ligands Protein-protein interface(s) links
Transferase PDB id
3rdp
Jmol
Contents
Protein chains
314 a.a.
Ligands
SO4 ×3
NMF ×2
Waters ×81
PDB id:
3rdp
Name: Transferase
Title: Crystal structure of thymidine kinase from herpes simplex vi in complex with n-methyl-fhbt
Structure: Thymidine kinase. Chain: a, b. Fragment: unp residues 46-376. Engineered: yes
Source: Human herpesvirus 1. Hhv-1. Organism_taxid: 10299. Strain: strain 17. Gene: tk, ul23. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.80Å     R-factor:   0.202     R-free:   0.244
Authors: L.Pernot,R.Perozzo,Y.Westermaier,M.Martic,S.Ametamey,L.Scapo
Key ref: M.Martić et al. (2011). Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids, 30, 293-315. PubMed id: 21623543
Date:
01-Apr-11     Release date:   03-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P03176  (KITH_HHV11) -  Thymidine kinase
Seq:
Struc:
376 a.a.
314 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.21  - Thymidine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + thymidine = ADP + thymidine 5'-phosphate
ATP
+
thymidine
Bound ligand (Het Group name = NMF)
matches with 50.00% similarity
= ADP
+ thymidine 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     TMP biosynthetic process   1 term 
  Biochemical function     ATP binding     2 terms  

 

 
    reference    
 
 
Nucleosides Nucleotides Nucleic Acids 30:293-315 (2011)
PubMed id: 21623543  
 
 
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
M.Martić, L.Pernot, Y.Westermaier, R.Perozzo, T.G.Kraljević, S.Krištafor, S.Raić-Malić, L.Scapozza, S.Ametamey.
 
  ABSTRACT  
 
No abstract given.