spacer
spacer

PDBsum entry 3qxd

Go to PDB code: 
protein Protein-protein interface(s) links
Immune system PDB id
3qxd
Jmol
Contents
Protein chains
178 a.a.
189 a.a.
14 a.a.
Waters ×462
PDB id:
3qxd
Name: Immune system
Title: F54c hla-dr1 bound with clip peptide
Structure: Hla class ii histocompatibility antigen, dr alpha chain: a, d. Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Mutation: yes. Hla class ii histocompatibility antigen, drb1-1 b chain: b, e. Fragment: unp residues 30-219.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dr1, hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: hla-dr1, hla-drb1. Synthetic: yes. Other_details: this chemically synthesized sequence occurs
Resolution:
2.30Å     R-factor:   0.190     R-free:   0.221
Authors: C.A.Painter,L.J.Stern
Key ref: C.A.Painter et al. (2011). Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc Natl Acad Sci U S A, 108, 19329-19334. PubMed id: 22084083 DOI: 10.1073/pnas.1108074108
Date:
01-Mar-11     Release date:   16-Nov-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
Seq:
Struc:
254 a.a.
178 a.a.*
Protein chains
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
Seq:
Struc:
266 a.a.
189 a.a.
Protein chains
Pfam   ArchSchema ?
P04233  (HG2A_HUMAN) -  HLA class II histocompatibility antigen gamma chain
Seq:
Struc:
296 a.a.
14 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   2 terms 
  Biological process     immune response   2 terms 

 

 
DOI no: 10.1073/pnas.1108074108 Proc Natl Acad Sci U S A 108:19329-19334 (2011)
PubMed id: 22084083  
 
 
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
C.A.Painter, M.P.Negroni, K.A.Kellersberger, Z.Zavala-Ruiz, J.E.Evans, L.J.Stern.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23222639 A.I.Guce, S.E.Mortimer, T.Yoon, C.A.Painter, W.Jiang, E.D.Mellins, and L.J.Stern (2013).
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
  Nat Struct Mol Biol, 20, 90-98.
PDB code: 4i0p
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.