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PDBsum entry 3qwk

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protein ligands links
Transferase/transferase inhibitor PDB id
3qwk
Jmol
Contents
Protein chain
294 a.a.
Ligands
EDO ×4
X62
Waters ×172
PDB id:
3qwk
Name: Transferase/transferase inhibitor
Title: Cdk2 in complex with inhibitor kvr-1-150
Structure: Cyclin-dependent kinase 2. Chain: a. Synonym: cdk2, cell division protein kinase 2, p33 protein engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.85Å     R-factor:   0.207     R-free:   0.235
Authors: S.Betzi,R.Alam,H.Han,A.Becker,E.Schonbrunn
Key ref: E.Schonbrunn et al. Structure-Guided optimization of novel cdk2 inhibitor discovered by high-Throughput screening. To be published, .
Date:
28-Feb-11     Release date:   08-Aug-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
294 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   14 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms