spacer
spacer

PDBsum entry 3qud

Go to PDB code: 
protein ligands links
Transferase PDB id
3qud
Jmol
Contents
Protein chain
345 a.a.
Ligands
BOG ×2
N3F
Waters ×103
PDB id:
3qud
Name: Transferase
Title: Human p38 map kinase in complex with 2-amino-phenylamino-ben
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti- inflammatory drug-binding protein, csaid-binding protein, c kinase mxi2, max-interacting protein 2, mitogen-activated p kinase p38 alpha, map kinase p38 alpha, sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.00Å     R-factor:   0.234     R-free:   0.278
Authors: C.Gruetter,D.Rauh
Key ref: S.C.Karcher et al. Resolving the selectivity problem for p38 mitogen act protein (map) kinase-Inhibitors: development of new h potent inhibitors of p38 map kinase with an outstandi selectivity profile. To be published, .
Date:
23-Feb-11     Release date:   11-Apr-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
345 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms