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PDBsum entry 3qmz

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protein Protein-protein interface(s) links
Motor protein PDB id
3qmz
Jmol
Contents
Protein chains
2136 a.a.
216 a.a.
PDB id:
3qmz
Name: Motor protein
Title: Crystal structure of the cytoplasmic dynein heavy chain moto
Structure: Cytoplasmic dynein heavy chain. Chain: a, b. Fragment: unp residues 1364-4092. Engineered: yes. Glutathione-s-transferase. Chain: t, s. Engineered: yes
Source: Saccharomyces cerevisiae. Organism_taxid: 4932. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Schistosoma japonicum. Organism_taxid: 6182. Expression_system_taxid: 4932
Resolution:
6.00Å     R-factor:   0.430     R-free:   0.430
Authors: C.Cho,A.P.Carter,L.Jin,R.D.Vale
Key ref: A.P.Carter et al. (2011). Crystal structure of the dynein motor domain. Science, 331, 1159-1165. PubMed id: 21330489
Date:
07-Feb-11     Release date:   16-Mar-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P36022  (DYHC_YEAST) -  Dynein heavy chain, cytoplasmic
Seq:
Struc:
 
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Seq:
Struc:
4092 a.a.
2136 a.a.*
Protein chains
Pfam   ArchSchema ?
P08515  (GST26_SCHJA) -  Glutathione S-transferase class-mu 26 kDa isozyme
Seq:
Struc:
218 a.a.
216 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure
* PDB and UniProt seqs differ at 9 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains T, S: E.C.2.5.1.18  - Glutathione transferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: RX + glutathione = HX + R-S-glutathione
RX
+ glutathione
= HX
+ R-S-glutathione
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     axonemal dynein complex   2 terms 
  Biological process     metabolic process   3 terms 
  Biochemical function     nucleotide binding     7 terms  

 

 
    reference    
 
 
Science 331:1159-1165 (2011)
PubMed id: 21330489  
 
 
Crystal structure of the dynein motor domain.
A.P.Carter, C.Cho, L.Jin, R.D.Vale.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22426545 H.Schmidt, E.S.Gleave, and A.P.Carter (2012).
Insights into dynein motor domain function from a 3.3-Å crystal structure.
  Nat Struct Mol Biol, 19, 492.
PDB codes: 4ai6 4akg 4akh 4aki
22551707 P.Höök, and R.Vallee (2012).
Dynein dynamics.
  Nat Struct Mol Biol, 19, 467-469.  
22373868 R.B.Vallee, R.J.McKenney, and K.M.Ori-McKenney (2012).
Multiple modes of cytoplasmic dynein regulation.
  Nat Cell Biol, 14, 224-230.  
22398446 T.Kon, T.Oyama, R.Shimo-Kon, K.Imamula, T.Shima, K.Sutoh, and G.Kurisu (2012).
The 2.8‚ÄČÅ crystal structure of the dynein motor domain.
  Nature, 484, 345-350.
PDB codes: 3vkg 3vkh
22231401 W.Qiu, N.D.Derr, B.S.Goodman, E.Villa, D.Wu, W.Shih, and S.L.Reck-Peterson (2012).
Dynein achieves processive motion using both stochastic and coordinated stepping.
  Nat Struct Mol Biol, 19, 193-200.  
21385703 J.A.Spudich (2011).
Biochemistry. Molecular motors, beauty in complexity.
  Science, 331, 1143-1144.  
21968990 K.Nasmyth (2011).
Cohesin: a catenase with separate entry and exit gates?
  Nat Cell Biol, 13, 1170-1177.  
21642959 N.Billington, and J.R.Sellers (2011).
Dynein struts its stuff.
  Nat Struct Mol Biol, 18, 635-636.  
21602819 T.Kon, K.Sutoh, and G.Kurisu (2011).
X-ray structure of a functional full-length dynein motor domain.
  Nat Struct Mol Biol, 18, 638-642.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.