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PDBsum entry 3qfs

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protein ligands links
Oxidoreductase PDB id
3qfs
Jmol
Contents
Protein chain
435 a.a.
Ligands
FAD
NAP
Waters ×424
PDB id:
3qfs
Name: Oxidoreductase
Title: Crystal structure of NADPH-cytochrome p450 reductase (fad/na domain)
Structure: NADPH--cytochrome p450 reductase. Chain: a. Fragment: fad/NADPH domain (unp residues 241-677). Synonym: cpr, p450r. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: por, cypor. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.40Å     R-factor:   0.211     R-free:   0.231
Authors: C.Xia,C.Marohnic,S.P.Panda,B.S.Masters,J.-J.P.Kim
Key ref: C.Xia et al. (2011). Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A, 108, 13486-13491. PubMed id: 21808038
Date:
22-Jan-11     Release date:   17-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P16435  (NCPR_HUMAN) -  NADPH--cytochrome P450 reductase
Seq:
Struc:
 
Seq:
Struc:
677 a.a.
435 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.6.2.4  - NADPH--hemoprotein reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
NADPH
+ n oxidized hemoprotein
= NADP(+)
+ n reduced hemoprotein
      Cofactor: FAD; FMN
FAD
Bound ligand (Het Group name = FAD) corresponds exactly
FMN
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   1 term 
  Biochemical function     oxidoreductase activity     1 term  

 

 
    reference    
 
 
Proc Natl Acad Sci U S A 108:13486-13491 (2011)
PubMed id: 21808038  
 
 
Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
C.Xia, S.P.Panda, C.C.Marohnic, P.Martásek, B.S.Masters, J.J.Kim.
 
  ABSTRACT  
 
No abstract given.