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PDBsum entry 3qe2

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase PDB id
3qe2
Jmol
Contents
Protein chains
604 a.a.
Ligands
FAD ×2
FMN ×2
NAP ×2
Metals
_CA
Waters ×966
PDB id:
3qe2
Name: Oxidoreductase
Title: Crystal structure of human NADPH-cytochrome p450 reductase
Structure: NADPH--cytochrome p450 reductase. Chain: a, b. Fragment: unp residues 64-677. Synonym: cpr, p450r. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: por, cypor. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.75Å     R-factor:   0.211     R-free:   0.239
Authors: C.Xia,C.Marohnic,S.P.Panda,B.S.Masters,J.-J.P.Kim
Key ref: C.Xia et al. (2011). Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A, 108, 13486-13491. PubMed id: 21808038
Date:
19-Jan-11     Release date:   03-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P16435  (NCPR_HUMAN) -  NADPH--cytochrome P450 reductase
Seq:
Struc:
 
Seq:
Struc:
677 a.a.
604 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.6.2.4  - NADPH--hemoprotein reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
NADPH
+ n oxidized hemoprotein
= NADP(+)
+ n reduced hemoprotein
      Cofactor: FAD; FMN
FAD
Bound ligand (Het Group name = FAD) corresponds exactly
FMN
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   5 terms 
  Biological process     regulation of growth plate cartilage chondrocyte proliferation   24 terms 
  Biochemical function     electron carrier activity     13 terms  

 

 
    reference    
 
 
Proc Natl Acad Sci U S A 108:13486-13491 (2011)
PubMed id: 21808038  
 
 
Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
C.Xia, S.P.Panda, C.C.Marohnic, P.Martásek, B.S.Masters, J.J.Kim.
 
  ABSTRACT  
 
No abstract given.