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PDBsum entry 3qcm

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protein ligands Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3qcm
Jmol
Contents
Protein chain
286 a.a.
Ligands
NXW ×2
MES ×2
Waters ×93
PDB id:
3qcm
Name: Hydrolase/hydrolase inhibitor
Title: Human receptor protein tyrosine phosphatase gamma, domain 1, complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-{[3-({n-[2- (methylamino)ethyl]glycyl}amino)phenyl]ethynyl}benzoic acid
Structure: Receptor-type tyrosine-protein phosphatase gamma. Chain: a, b. Synonym: protein-tyrosine phosphatase gamma, r-ptp-gamma. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpg, ptprg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.40Å     R-factor:   0.201     R-free:   0.244
Authors: S.Sheriff
Key ref: S.Sheriff et al. (2011). Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop. J Med Chem, 54, 6548-6562. PubMed id: 21882820
Date:
16-Jan-11     Release date:   28-Dec-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P23470  (PTPRG_HUMAN) -  Receptor-type tyrosine-protein phosphatase gamma
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1445 a.a.
286 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms  

 

 
    reference    
 
 
J Med Chem 54:6548-6562 (2011)
PubMed id: 21882820  
 
 
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
S.Sheriff, B.R.Beno, W.Zhai, W.A.Kostich, P.A.McDonnell, K.Kish, V.Goldfarb, M.Gao, S.E.Kiefer, J.Yanchunas, Y.Huang, S.Shi, S.Zhu, C.Dzierba, J.Bronson, J.E.Macor, K.K.Appiah, R.S.Westphal, J.O'Connell, S.W.Gerritz.
 
  ABSTRACT  
 
No abstract given.