PDBsum entry 3qb5

Hydrolase

PDB id

3qb5

Loading ...

Contents

			Protein chains

					213 a.a.


					222 a.a.

			Ligands

					PO4 ×2


					SO4 ×2

			Metals

					_NA


					_CL


					_MN

			Waters ×20

PDB id:

3qb5

Links

Name:

Hydrolase

Title:

Human c3po complex in the presence of mnso4

Structure:

Translin. Chain: a, b, c. Engineered: yes. Translin-associated protein x. Chain: k. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tsn. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: tsnax, trax.

Resolution:

2.95Å

R-factor:

0.226

R-free:

0.273

Authors:

X.Ye,N.Huang,Y.Liu,Z.Paroo,S.Chen,H.Zhang,Q.Liu

Key ref:

X.Ye et al. (2011). Structure of C3PO and mechanism of human RISC activation. Nat Struct Biol, 18, 650-657. PubMed id: 21552258

Date:

12-Jan-11

Release date:

11-May-11

PROCHECK

	Headers

	References

Protein chains

Q15631 (TSN_HUMAN) - Translin from Homo sapiens

Seq: Struc:					228 a.a. 213 a.a.

Protein chain

Q99598 (TSNAX_HUMAN) - Translin-associated protein X from Homo sapiens

Seq: Struc:					290 a.a. 222 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

Chains A, B, C: E.C.3.1.-.-

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Nat Struct Biol 18:650-657 (2011)
PubMed id: 21552258

Structure of C3PO and mechanism of human RISC activation.
X.Ye, N.Huang, Y.Liu, Z.Paroo, C.Huerta, P.Li, S.Chen, Q.Liu, H.Zhang.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22484317

D.Gibbings, P.Leblanc, F.Jay, D.Pontier, F.Michel, Y.Schwab, S.Alais, T.Lagrange, and O.Voinnet (2012).
Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.

Nat Struct Mol Biol, 19, 517.

22773104

L.Li, W.Gu, C.Liang, Q.Liu, C.C.Mello, and Y.Liu (2012).
The translin-TRAX complex (C3PO) is a ribonuclease in tRNA processing.

Nat Struct Mol Biol, 19, 824-830.

22233755

P.B.Kwak, and Y.Tomari (2012).
The N domain of Argonaute drives duplex unwinding during RISC assembly.

Nat Struct Mol Biol, 19, 145-151.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.