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PDBsum entry 3q7d

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase/oxidoreductase inhibitor PDB id
3q7d
Jmol
Contents
Protein chains
552 a.a.
Ligands
NAG ×8
HEM ×2
NPX ×2
BOG ×5
Metals
_CL ×2
Waters ×598
PDB id:
3q7d
Name: Oxidoreductase/oxidoreductase inhibitor
Title: Structure of (r)-naproxen bound to mcox-2.
Structure: Prostaglandin g/h synthase 2. Chain: a, b. Synonym: cyclooxygenase-2, cox-2, glucocorticoid-regulated inflammatory cyclooxygenase, gripghs, macrophage activation associated marker protein p71/73, pes-2, phs ii, prostaglan synthase 2, pgh synthase 2, pghs-2, prostaglandin-endoperox synthase 2, tis10 protein. Engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ptgs2, cox-2, cox2, pghs-b, tis10. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
2.40Å     R-factor:   0.180     R-free:   0.233
Authors: K.C.Duggan,D.J.Hermanson,J.Musee,J.J.Prusakiewicz,J.Scheib, B.D.Carter,S.Banerjee,L.J.Marnett
Key ref: k.c.duggan et al. (2011). Our professional opinion. Nat Chem Biol, 7, 649-809. PubMed id: 21931302 DOI: 10.1038/nchembio.663
Date:
04-Jan-11     Release date:   09-Nov-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q05769  (PGH2_MOUSE) -  Prostaglandin G/H synthase 2
Seq:
Struc:
 
Seq:
Struc:
604 a.a.
552 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.14.99.1  - Prostaglandin-endoperoxide synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Arachidonate
Bound ligand (Het Group name = HEM)
matches with 51.16% similarity
+ AH(2)
+ 2 × O(2)
= prostaglandin H(2)
+
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     protein complex   8 terms 
  Biological process     maintenance of blood-brain barrier   64 terms 
  Biochemical function     lipid binding     10 terms  

 

 
    reference    
 
 
DOI no: 10.1038/nchembio.663 Nat Chem Biol 7:649-809 (2011)
PubMed id: 21931302  
 
 
Our professional opinion.
k.c.duggan, d.j.hermanson, j.musee, j.j.prusakiewicz, j.l.scheib, b.d.carter, s.banerjee, j.a.oates, l.j.marnet.
 
  ABSTRACT  
 
No abstract given.