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PDBsum entry 3pyg

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protein ligands links
Transferase PDB id
3pyg
Jmol
Contents
Protein chain
298 a.a.
Ligands
ADP
Waters ×168
PDB id:
3pyg
Name: Transferase
Title: Mycobacterium tuberculosis 4-diphosphocytidyl-2-c-methyl-d-e kinase (ispe) in complex with adp
Structure: 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase chain: a. Synonym: ispe, cmk, 4-(cytidine-5'-diphospho)-2-c-methyl-d- kinase. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: ispe, rv1011, mt1040, mtci237.28. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.99Å     R-factor:   0.222     R-free:   0.263
Authors: S.Shan,X.H.Chen,T.Liu,H.C.Zhao,Z.H.Rao,Z.Y.Lou
Key ref: S.Shan et al. The structural basis for anti-Tb drug discovery targe 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol kinase (is from mycobacterium tuberculosis. To be published, .
Date:
13-Dec-10     Release date:   25-Jan-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam  
P9WKG7  (ISPE_MYCTU) -  4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Seq:
Struc:
306 a.a.
298 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.148  - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
ATP
+ 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
=
ADP
Bound ligand (Het Group name = ADP)
corresponds exactly
+ 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
      Cofactor: Mn(2+) or Mg(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     isoprenoid biosynthetic process   4 terms 
  Biochemical function     nucleotide binding     5 terms