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PDBsum entry 3py0

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protein ligands links
Transferase/transferase inhibitor PDB id
3py0
Jmol
Contents
Protein chain
294 a.a. *
Ligands
EDO
PO4
SU9
Waters ×170
* Residue conservation analysis
PDB id:
3py0
Name: Transferase/transferase inhibitor
Title: Cdk2 in complex with inhibitor su9516
Structure: Cell division protein kinase 2. Chain: a. Synonym: cdk2, p33 protein kinase. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.75Å     R-factor:   0.212     R-free:   0.260
Authors: S.Betzi,R.Alam,E.Schonbrunn
Key ref: S.Betzi et al. (2011). Discovery of a potential allosteric ligand binding site in CDK2. ACS Chem Biol, 6, 492-501. PubMed id: 21291269
Date:
10-Dec-10     Release date:   16-Feb-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
294 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms  

 

 
    reference    
 
 
ACS Chem Biol 6:492-501 (2011)
PubMed id: 21291269  
 
 
Discovery of a potential allosteric ligand binding site in CDK2.
S.Betzi, R.Alam, M.Martin, D.J.Lubbers, H.Han, S.R.Jakkaraj, G.I.Georg, E.Schönbrunn.
 
  ABSTRACT  
 
No abstract given.