PDBsum entry 3pwn

Protein binding

PDB id: 3pwn

Contents

Protein chains

275 a.a.

100 a.a.

Ligands

LEU-LEU-TYR-GLY-PHE-VAL-ASN-TYR-ILE ×2

GOL ×5

Waters ×777

PDB id:

3pwn

Name:

Protein binding

Title:

Human class i mhc hla-a2 in complex with the hud (g2l) peptide variant

Structure:

Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a, d. Synonym: mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b, e. Synonym: beta-2-microglobulin form pi 5.3. Engineered: yes. Hud (g2l) peptide.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes

Resolution:

1.60Å R-factor: 0.181 R-free: 0.214

Authors:

O.Y.Borbulevych,B.M.Baker

Key ref:

O.Y.Borbulevych et al. (2011). Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics. J Immunol, 186, 2950-2958. PubMed id: 21282516

Date:

08-Dec-10 Release date: 09-Mar-11

Protein chains

P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: 365 a.a.

Struc: 275 a.a.*

Protein chains

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

* PDB and UniProt seqs differ at 20 residue positions (black crosses)

J Immunol 186:2950-2958 (2011)

PubMed id: 21282516

Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.

O.Y.Borbulevych, K.H.Piepenbrink, B.M.Baker.

ABSTRACT

No abstract given.