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PDBsum entry 3pnb

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protein ligands Protein-protein interface(s) links
Transferase PDB id
3pnb
Jmol
Contents
Protein chains
157 a.a.
Ligands
COA ×4
Waters ×372
PDB id:
3pnb
Name: Transferase
Title: Phosphopantetheine adenylyltransferase from mycobacterium tu in complex with coenzyme a
Structure: Phosphopantetheine adenylyltransferase. Chain: a, b, c, d. Synonym: dephospho-coa pyrophosphorylase, pantetheine-phosp adenylyltransferase, ppat. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.11Å     R-factor:   0.216     R-free:   0.248
Authors: T.J.Wubben,A.D.Mesecar
Key ref: T.Wubben and A.D.Mesecar (2011). Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation. Acta Crystallogr Sect F Struct Biol Cryst Commun, 67, 541-545. PubMed id: 21543857
Date:
18-Nov-10     Release date:   22-Jun-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam  
P9WPA5  (COAD_MYCTU) -  Phosphopantetheine adenylyltransferase
Seq:
Struc:
161 a.a.
157 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.7.3  - Pantetheine-phosphate adenylyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Coenzyme A Biosynthesis (late stages)
      Reaction: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
ATP
Bound ligand (Het Group name = COA)
matches with 51.92% similarity
+ pantetheine 4'-phosphate
= diphosphate
+ 3'-dephospho-CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     biosynthetic process   3 terms 
  Biochemical function     catalytic activity     6 terms  

 

 
    reference    
 
 
Acta Crystallogr Sect F Struct Biol Cryst Commun 67:541-545 (2011)
PubMed id: 21543857  
 
 
Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation.
T.Wubben, A.D.Mesecar.
 
  ABSTRACT  
 
No abstract given.