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PDBsum entry 3pjj

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protein ligands metals links
Lyase PDB id
3pjj
Jmol
Contents
Protein chain
258 a.a.
Ligands
MZH
Metals
_ZN
Waters ×201
PDB id:
3pjj
Name: Lyase
Title: Synthetic dimer of human carbonic anhydrase ii
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, ca carbonic anhydrase ii, ca-ii. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.80Å     R-factor:   0.222     R-free:   0.283
Authors: P.W.Snyder,R.L.Kwant,D.T.Moustakas,E.T.Mack,M.J.Butte,G.W.Wh
Key ref: P.W.Snyder et al. One interface stabilizes linear chains in all polymor crystals of human carbonic anhydrase ii. To be published, .
Date:
10-Nov-10     Release date:   18-Jan-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
258 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zinc
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   10 terms 
  Biological process     angiotensin-mediated signaling pathway   20 terms 
  Biochemical function     protein binding     5 terms