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PDBsum entry 3pj8

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protein ligands links
Transferase/transferase inhibitor PDB id
3pj8
Jmol
Contents
Protein chain
288 a.a.
Ligands
404
Waters ×146
PDB id:
3pj8
Name: Transferase/transferase inhibitor
Title: Structure of cdk2 in complex with a pyrazolo[4,3-d]pyrimidin bioisostere of roscovitine.
Structure: Cell division protein kinase 2. Chain: a. Synonym: p33 protein kinase. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.96Å     R-factor:   0.206     R-free:   0.273
Authors: I.W.Mcnae,R.Jorda,L.Havlicek,M.Strnad,J.Voller,M.D.Walkinsha V.Krystof
Key ref: R.Jorda et al. (2011). Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity. J Med Chem, 54, 2980-2993. PubMed id: 21417417 DOI: 10.1021/jm200064p
Date:
09-Nov-10     Release date:   06-Apr-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
288 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms  

 

 
    reference    
 
 
DOI no: 10.1021/jm200064p J Med Chem 54:2980-2993 (2011)
PubMed id: 21417417  
 
 
Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.
R.Jorda, L.Havlícek, I.W.McNae, M.D.Walkinshaw, J.Voller, A.Sturc, J.Navrátilová, M.Kuzma, M.Mistrík, J.Bártek, M.Strnad, V.Krystof.
 
  ABSTRACT  
 
No abstract given.