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PDBsum entry 3pgc

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protein ligands Protein-protein interface(s) links
Immune system PDB id
3pgc
Jmol
Contents
Protein chains
177 a.a. *
184 a.a. *
15 a.a. *
Ligands
PEG
GOL
Waters ×115
* Residue conservation analysis
PDB id:
3pgc
Name: Immune system
Title: Crystal structure of hla-dr1 with clip106-120, flipped pepti orientation
Structure: Hla class ii histocompatibility antigen, dr alpha chain: a, d. Fragment: unp residues 26-217. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 b chain: b, e. Fragment: unp residues 30-227. Synonym: mhc class ii antigen drb1 1, Dr-1, dr1.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: hla-drb1. Synthetic: yes. Organism_taxid: 9606
Resolution:
2.66Å     R-factor:   0.201     R-free:   0.250
Authors: S.Gunther,A.Schlundt,J.Sticht,Y.Roske,U.Heinemann,K.-H.Wiesm G.Jung,K.Falk,O.Rotzschke,C.Freund
Key ref: S.Günther et al. (2010). Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc Natl Acad Sci U S A, 107, 22219-22224. PubMed id: 21115828
Date:
01-Nov-10     Release date:   08-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
Seq:
Struc:
254 a.a.
177 a.a.
Protein chains
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
Seq:
Struc:
266 a.a.
184 a.a.
Protein chains
Pfam   ArchSchema ?
P04233  (HG2A_HUMAN) -  HLA class II histocompatibility antigen gamma chain
Seq:
Struc:
296 a.a.
15 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   2 terms 
  Biological process     immune response   2 terms 

 

 
Proc Natl Acad Sci U S A 107:22219-22224 (2010)
PubMed id: 21115828  
 
 
Bidirectional binding of invariant chain peptides to an MHC class II molecule.
S.Günther, A.Schlundt, J.Sticht, Y.Roske, U.Heinemann, K.H.Wiesmüller, G.Jung, K.Falk, O.Rötzschke, C.Freund.
 
  ABSTRACT  
 
No abstract given.