PDBsum entry 3pgc

Immune system

PDB id: 3pgc

Contents

Protein chains

177 a.a. *

184 a.a. *

15 a.a. *

Ligands

PEG

GOL

Waters ×115

* Residue conservation analysis

PDB id:

3pgc

Name:

Immune system

Title:

Crystal structure of hla-dr1 with clip106-120, flipped peptide orientation

Structure:

Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d. Fragment: unp residues 26-217. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: unp residues 30-227. Synonym: mhc class ii antigen drb1 1, Dr-1, dr1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: hla-drb1. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.66Å R-factor: 0.201 R-free: 0.250

Authors:

S.Gunther,A.Schlundt,J.Sticht,Y.Roske,U.Heinemann,K.-H.Wiesmuller, G.Jung,K.Falk,O.Rotzschke,C.Freund

Key ref:

S.Günther et al. (2010). Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc Natl Acad Sci U S A, 107, 22219-22224. PubMed id: 21115828

Date:

01-Nov-10 Release date: 08-Dec-10

Protein chains

P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain from Homo sapiens

Seq: 254 a.a.

Struc: 177 a.a.

Protein chains

P01911  (2B1F_HUMAN) -  HLA class II histocompatibility antigen, DRB1 beta chain from Homo sapiens

Seq: 266 a.a.

Struc: 184 a.a.*

Protein chains

P04233  (HG2A_HUMAN) -  HLA class II histocompatibility antigen gamma chain from Homo sapiens

Seq: 296 a.a.

Struc: 15 a.a.

* PDB and UniProt seqs differ at 13 residue positions (black crosses)

Proc Natl Acad Sci U S A 107:22219-22224 (2010)

PubMed id: 21115828

Bidirectional binding of invariant chain peptides to an MHC class II molecule.

S.Günther, A.Schlundt, J.Sticht, Y.Roske, U.Heinemann, K.H.Wiesmüller, G.Jung, K.Falk, O.Rötzschke, C.Freund.

ABSTRACT

No abstract given.