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PDBsum entry 3p44

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protein ligands metals links
Lyase PDB id
3p44
Jmol
Contents
Protein chain
257 a.a.
Ligands
067
GOL ×2
Metals
_ZN
Waters ×122
PDB id:
3p44
Name: Lyase
Title: Human carbonic anhydrase ii in complex with p-(4-ruthenoceny 3-triazol-1-yl)benzenesulfonamide
Structure: Carbonic anhydrase 2. Chain: a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.20Å     R-factor:   0.183     R-free:   0.233
Authors: A.J.Salmon
Key ref: A.J.Salmon et al. (2012). Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors. Chem Commun (Camb), 48, 2328-2330. PubMed id: 22258283
Date:
06-Oct-10     Release date:   12-Oct-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   21 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
Chem Commun (Camb) 48:2328-2330 (2012)
PubMed id: 22258283  
 
 
Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors.
A.J.Salmon, M.L.Williams, A.Hofmann, S.A.Poulsen.
 
  ABSTRACT  
 
No abstract given.