PDBsum entry 3p3h

Lyase

PDB id: 3p3h

Contents

Protein chain

258 a.a.

Ligands

84A

GOL

Metals

_ZN

Waters ×369

PDB id:

3p3h

Name:

Lyase

Title:

Human carbonic anhydrase ii in complex with p-(5-ferrocenyl-1h-1,2,3- triazol-1-yl)benzenesulfonamide

Structure:

Carbonic anhydrase 2. Chain: a. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratase ii, carbonic anhydrasE C, cac. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.50Å R-factor: 0.177 R-free: 0.201

Authors:

A.J.Salmon

Key ref:

A.J.Salmon et al. (2012). Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors. Chem Commun (camb), 48, 2328-2330. PubMed id: 22258283

Date:

04-Oct-10 Release date: 28-Sep-11

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Chem Commun (camb) 48:2328-2330 (2012)

PubMed id: 22258283

Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors.

A.J.Salmon, M.L.Williams, A.Hofmann, S.A.Poulsen.

ABSTRACT

No abstract given.