PDBsum entry 3ozc

Transferase

PDB id: 3ozc

Contents

Protein chain

273 a.a.

Ligands

4CT

PO4

Waters ×67

PDB id:

3ozc

Name:

Transferase

Title:

Crystal structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pcl-phenylthiodadmeimma

Structure:

S-methyl-5'-thioadenosine phosphorylase. Chain: a. Synonym: 5'-methylthioadenosine phosphorylase, mta phosphorylase, mtapase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mtap, msap. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.93Å R-factor: 0.132 R-free: 0.154

Authors:

M.Ho,R.Guan,S.C.Almo,V.L.Schramm

Key ref:

M.Ho et al. Crystal structure of human 5'-Deoxy-5'-Methyladenosin phosphorylase. To be published, .

Date:

24-Sep-10 Release date: 28-Sep-11

Protein chain

Q13126  (MTAP_HUMAN) -  S-methyl-5'-thioadenosine phosphorylase from Homo sapiens

Seq: 283 a.a.

Struc: 273 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.2.28 - S-methyl-5'-thioadenosine phosphorylase.
• Reaction: S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine

S-methyl-5'-thioadenosine (Bound ligand (Het Group name = PO4) corresponds exactly) + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine

Molecule diagrams generated from .mol files obtained from the KEGG ftp site