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PDBsum entry 3oy1

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protein ligands links
Transherase/transferase inhibitor PDB id
3oy1
Jmol
Contents
Protein chain
329 a.a.
Ligands
589
Waters ×205
PDB id:
3oy1
Name: Transherase/transferase inhibitor
Title: Highly selectivE C-jun n-terminal kinase (jnk) 2 and 3 inhib in vitro cns-like pharmacokinetic properties
Structure: Mitogen-activated protein kinase 10. Chain: a. Fragment: unp residues 40-401. Synonym: map kinase 10, mapk 10, stress-activated protein k jnk3, c-jun n-terminal kinase 3, map kinase p49 3f12. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.70Å     R-factor:   0.259     R-free:   0.299
Authors: G.D.Probst,S.Bowers,J.M.Sealy,A.Truong,J.Neitz,R.K.Hom,R.A.G Jr.,A.W.Konradi,H.L.Sham,D.Quincy,H.Pan,N.Yao
Key ref: G.D.Probst et al. (2011). Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg Med Chem Lett, 21, 315-319. PubMed id: 21112785 DOI: 10.1016/j.bmcl.2010.11.010
Date:
22-Sep-10     Release date:   17-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P53779  (MK10_HUMAN) -  Mitogen-activated protein kinase 10
Seq:
Struc:
464 a.a.
329 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     5 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.bmcl.2010.11.010 Bioorg Med Chem Lett 21:315-319 (2011)
PubMed id: 21112785  
 
 
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
G.D.Probst, S.Bowers, J.M.Sealy, A.P.Truong, R.K.Hom, R.A.Galemmo, A.W.Konradi, H.L.Sham, D.A.Quincy, H.Pan, N.Yao, M.Lin, G.Tóth, D.R.Artis, W.Zmolek, K.Wong, A.Qin, C.Lorentzen, D.F.Nakamura, K.P.Quinn, J.M.Sauer, K.Powell, L.Ruslim, S.Wright, D.Chereau, Z.Ren, J.P.Anderson, F.Bard, T.A.Yednock, I.Griswold-Prenner.
 
  ABSTRACT  
 
No abstract given.