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PDBsum entry 3own

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protein ligands metals Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3own
Jmol
Contents
Protein chain
334 a.a. *
Ligands
ACT ×3
3OX
3OW
Metals
_NA ×2
Waters ×343
* Residue conservation analysis
PDB id:
3own
Name: Hydrolase/hydrolase inhibitor
Title: Potent macrocyclic renin inhibitors
Structure: Renin. Chain: a, b. Fragment: unp residues 67-406. Synonym: angiotensinogenase. Ec: 3.4.23.15
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
2.00Å     R-factor:   0.219     R-free:   0.254
Authors: N.Borkakoti,D.Derbyshire
Key ref: C.Sund et al. (2011). Design and synthesis of potent macrocyclic renin inhibitors. Bioorg Med Chem Lett, 21, 358-362. PubMed id: 21112780 DOI: 10.1016/j.bmcl.2010.10.140
Date:
20-Sep-10     Release date:   15-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00797  (RENI_HUMAN) -  Renin
Seq:
Struc:
406 a.a.
334 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.4.23.15  - Renin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Cleaves Leu-|- bond in angiotensinogen to generate angiotensin I.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     proteolysis   1 term 
  Biochemical function     aspartic-type endopeptidase activity     1 term  

 

 
DOI no: 10.1016/j.bmcl.2010.10.140 Bioorg Med Chem Lett 21:358-362 (2011)
PubMed id: 21112780  
 
 
Design and synthesis of potent macrocyclic renin inhibitors.
C.Sund, O.Belda, D.Wiktelius, C.Sahlberg, L.Vrang, S.Sedig, E.Hamelink, I.Henderson, T.Agback, K.Jansson, N.Borkakoti, D.Derbyshire, A.Eneroth, B.Samuelsson.
 
  ABSTRACT  
 
No abstract given.