PDBsum entry 3oqf

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Hydrolase PDB id
Protein chain
337 a.a. *
NAG ×2
S51 ×2
Waters ×195
* Residue conservation analysis
PDB id:
Name: Hydrolase
Title: Crystal structure analysis of renin-indole-piperazine inhibi complexes
Structure: Renin. Chain: a, b. Fragment: unp residues 67-406. Synonym: angiotensinogenase. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cell (c
2.78Å     R-factor:   0.181     R-free:   0.201
Authors: Z.Bocskei
Key ref: B.Scheiper et al. (2010). Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorg Med Chem Lett, 20, 6268-6272. PubMed id: 20850300 DOI: 10.1016/j.bmcl.2010.08.092
03-Sep-10     Release date:   13-Oct-10    
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Protein chains
Pfam   ArchSchema ?
P00797  (RENI_HUMAN) -  Renin
406 a.a.
337 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.  - Renin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Cleaves Leu-|- bond in angiotensinogen to generate angiotensin I.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     proteolysis   1 term 
  Biochemical function     aspartic-type endopeptidase activity     1 term  


DOI no: 10.1016/j.bmcl.2010.08.092 Bioorg Med Chem Lett 20:6268-6272 (2010)
PubMed id: 20850300  
Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.
B.Scheiper, H.Matter, H.Steinhagen, U.Stilz, Z.Böcskei, V.Fleury, G.McCort.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
21429746 R.Aspiotis, A.Chen, E.Cauchon, D.Dubé, J.P.Falgueyret, S.Gagné, M.Gallant, E.L.Grimm, R.Houle, H.Juteau, P.Lacombe, S.Laliberté, J.F.Lévesque, D.MacDonald, D.McKay, M.D.Percival, P.Roy, S.M.Soisson, and T.Wu (2011).
The discovery and synthesis of potent zwitterionic inhibitors of renin.
  Bioorg Med Chem Lett, 21, 2430-2436.  
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