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PDBsum entry 3oob

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protein ligands links
Isomerase PDB id
3oob
Jmol
Contents
Protein chain
146 a.a.
Ligands
SO4
PE4 ×3
KDH ×2
Waters ×112
PDB id:
3oob
Name: Isomerase
Title: Structural and functional insights of directly targeting pin epigallocatechin-3-gallate
Structure: Peptidyl-prolyl cis-trans isomerase nima-interact chain: a. Synonym: peptidyl-prolyl cis-trans isomerase pin1, ppiase p rotamase pin1. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pin1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.89Å     R-factor:   0.192     R-free:   0.232
Authors: D.V.Urusova,J.-H.Shim,D.-J.Kim,S.K.Jung,T.A.Zykova,A.M.Bode,
Key ref: D.V.Urusova et al. (2011). Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1. Cancer Prev Res (Phila), 4, 1366-1377. PubMed id: 21750208 DOI: 10.1158/1940-6207.CAPR-11-0301
Date:
30-Aug-10     Release date:   17-Aug-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q13526  (PIN1_HUMAN) -  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Seq:
Struc:
163 a.a.
146 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     midbody   5 terms 
  Biological process     negative regulation of cell motility   15 terms 
  Biochemical function     protein binding     7 terms  

 

 
    Added reference    
 
 
DOI no: 10.1158/1940-6207.CAPR-11-0301 Cancer Prev Res (Phila) 4:1366-1377 (2011)
PubMed id: 21750208  
 
 
Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.
D.V.Urusova, J.H.Shim, D.J.Kim, S.K.Jung, T.A.Zykova, A.Carper, A.M.Bode, Z.Dong.
 
  ABSTRACT  
 
No abstract given.