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PDBsum entry 3olr

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
3olr
Jmol
Contents
Protein chains
297 a.a.
Ligands
TYR-GLY-GLU-GLU-
PTR-ASP-ASP-LEU-
TYR
×3
TYR-GLY-GLU-GLU-
PTR-ASP-ASP-LEU
Waters ×395
PDB id:
3olr
Name: Hydrolase
Title: Ptpn22 in complex with consensus phospho-tyrosine peptide 1
Structure: Tyrosine-protein phosphatase non-receptor type 22 chain: a, b, c, d. Fragment: unp residues 1-294. Synonym: hematopoietic cell protein-tyrosine phosphatase 70 lymphoid phosphatase, lyp. Engineered: yes. Mutation: yes. Skap2. Chain: e, f, g, h.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn22, ptpn8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence is derived from a peptide scre
Resolution:
2.50Å     R-factor:   0.162     R-free:   0.210
Authors: X.Yu,J.-P.Sun,S.Zhang,Z.-Y.Zhang
Date:
26-Aug-10     Release date:   29-Jun-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9Y2R2  (PTN22_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 22
Seq:
Struc:
 
Seq:
Struc:
807 a.a.
297 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
Bound ligand (Het Group name = PTR)
matches with 76.19% similarity
+ H(2)O
=
protein tyrosine
Bound ligand (Het Group name = TYR)
matches with 70.59% similarity
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms